Three genes for lupus nephritis in NZB x NZW mice

Three Genes for Lupus Nephritis in Nzb × Nzw Mice

NZB x NZW hybrid mice provide an excellent model of spontaneous autoimmune disease, showing a very high incidence of a renal disorder which closely resembles lupus nephritis (1). The occurrence of an autoimmune condition, causing early death from renal failure, in the hybrid of two in-bred strains which do not themselves show the disorder provides a unique opportunity for elucidating the geneti...

Immunosuppression by cyclophosphamide in NZB X NZW mice with lupus nephritis.

Effects of MHC and gender on lupus-like autoimmunity in Nba2 congenic mice.

The lupus-like disease that develops in hybrids of NZB and NZW mice is genetically complex, involving both MHC- and non-MHC-encoded genes. Studies in this model have indicated that the H2d/z MHC type, compared with H2d/d or H2z/z, is critical for disease development. C57BL/6 (B6) mice (H2b/b) congenic for NZB autoimmunity 2 (Nba2), a NZB-derived susceptibility locus on distal chromosome 1, prod...

FcR-bearing myeloid cells are responsible for triggering murine lupus nephritis.

Lupus glomerulonephritis is initiated by deposition of IgG-containing immune complexes in renal glomeruli. FcR engagement by immune complexes (IC) is crucial to disease development as uncoupling this pathway in FcRgamma(-/-) abrogates inflammatory responses in (NZB x NZW)F1 mice. To define the roles of FcR-bearing hemopoietic cells and of kidney resident mesangial cells in pathogenesis, (NZB x ...

Control of separate pathogenic autoantibody responses marks MHC gene contributions to murine lupus.

Previous studies have suggested that MHC and non-MHC genes contribute to the development of autoimmune disease in F1 hybrids of New Zealand black (NZB) and white (NZW) mice. We conducted a genome-wide screen of 148 female (NZB x NZW)F1 x NZB backcross mice to map dominant NZW genetic loci linked with lupus disease traits. In this backcross analysis, inheritance of the NZW MHC (H2(d/z) vs. H2(d/...